I don't recommend Wine. But to answer you question. Yes mount the MS-Windows partition, then it will look like a regular directory. Point Wine at this directory. There may be problems caused by Gnu/Linux writing to this partition. So mount it read-only.

If you need to write to it (but not so MS-Windows can see), then use a union-file-system, to layer a write layer on top.

#A better solution If you want to keep MS-Windows, then put it in virtual-box.

I don't recommend Wine. But to answer you question. Yes mount the MS-Windows partition, then it will look like a regular directory. Point Wine at this directory. There may be problems caused by Gnu/Linux writing to this partition. So mount it read-only.

If you need to write to it (but not so MS-Windows can see), then use a union-file-system, to layer a write layer on top.

A better solution

If you want to keep MS-Windows, then put it in virtual-box.