I'm working with a dataframe which contains addresses and I want to delete a specfic part of a string. Like for example

And I want to delete the string since taking the words "REFERENCE:" and "reference:" to the end of the sentence. Also I want to create a new column that looks something like this (without the word REFERENCE:/reference: and the next letter of those words) Could you help me to do it in Regex?
I want that it the new column looks something like this:
