1 files changed, 5 insertions, 0 deletions
diff --git a/sources/pyside6/libpyside/pyside.cpp b/sources/pyside6/libpyside/pyside.cpp
index e92e0bfa4..42b7725cc 100644
--- a/sources/pyside6/libpyside/pyside.cpp
+++ b/sources/pyside6/libpyside/pyside.cpp
@@ -632,6 +632,11 @@ namespace PySide
 
 static void invalidatePtr(any_t *object)
 {
+    // PYSIDE-2254: Guard against QObjects outliving Python, for example the
+    // adopted main thread as returned by QObjects::thread().
+    if (Py_IsInitialized() == 0)
+        return;
+
     Shiboken::GilState state;
 
     SbkObject *wrapper = Shiboken::BindingManager::instance().retrieveWrapper(object);