You can write a straightforward regex to extract the URL.
>>> import re
>>> href = "javascript:void%20window.open('/Sheraton-Tucson-Hotel-177/tnc/150/24795/en','TC_POPUP','width=490,height=405,screenX=300,screenY=250,top=250,left=300,scrollbars=yes,resizable=no');"
>>> re.findall(r"'(.*?)'", href)
['/Sheraton-Tucson-Hotel-177/tnc/150/24795/en', 'TC_POPUP', 'width=490,height=405,screenX=300,screenY=250,top=250,left=300,scrollbars=yes,resizable=no']
>>> _[0]
'/Sheraton-Tucson-Hotel-177/tnc/150/24795/en'
The regex in question here is
'(.*?)'
Which reads "find a single-quote, followed by whatever (and capture the whatever), followed by another single quote, and do so non-greedily because of the ? operator". This extracts the arguments of window.open; then, just pick the first one to get the URL.
You shouldn't have any nested ' in your href, since those should be escaped to %27. If you do, though, this will not work, and you may need a solution that doesn't use regexes.
()and then explode it on the basis of,and then get first index value