Genentech

In a new study published in Nature Immunology, our scientists discovered that specialized cells called Gremlin1 (GREM1)-expressing fibroblastic reticular cells (FRCs) exist in specific areas of lymph nodes. These cells produce an important growth factor known as FLT3L, which is crucial for the survival of dendritic cells that help kickstart our immune responses. This research highlights how the spatial arrangement of these stromal and immune cells matters for effective responses to infection and immunization. The findings deepen our understanding of lymphoid organ biology and open up new opportunities to dissect how these cellular niches are disrupted in diseases. http://spr.ly/60427eWCM

Through our South San Francisco Civic Fund, we support local programs and events that foster connection, collaboration and pride across our local community. One of this year’s fund recipients was the annual Leap Sandcastle Classic – a hands-on event where elementary school students from across the Bay Area work alongside local STEM professionals, including Genentech volunteers, to dream up and build giant sand sculptures on the beach. The event brought together creativity, teamwork and a little friendly competition, all in the name of supporting arts and STEAM education for nearly 10,000 public school students. This is one example of how we champion STEAM learning right here in our backyard and inspire the next generation of innovators. Learn more about how Leap - Arts In Education is making an impact: http://spr.ly/60487k5Sq #SandcastleClassic2025 #STEAMeducation #LeapArtsinEducation

Veterans and active duty service members face higher rates of some health conditions, including certain cancers and multiple sclerosis, but barriers to navigating complex healthcare systems and stigma often prevent them from accessing the physical and mental health care they need. That’s why forging authentic partnerships with organizations that are dedicated to serving veterans in their own communities, like the Military Basketball Association (MBA), is a vital part of making healthcare more equitable and accessible. In honor of Veterans Day, hear from Mike Meyers II, Founder and Commissioner, MBA, on how meeting veterans where they are can help facilitate conversations about their health and close gaps in care. Learn more: http://spr.ly/60487Trfw

For Joachim Rudolph, science is much more than experiments and equations – it’s a synthesis of curiosity, creativity, and collaboration. As a Senior Fellow in Medicinal Chemistry, he leads a team of scientists pioneering new ways to harness small molecules against previously untreatable diseases and expand treatment options for patients. Beyond the lab, Joachim finds balance through music, sports, and time with his family, reminding him that discovery doesn’t just happen at the bench, but in life as well. Learn more about Joachim’s journey. http://spr.ly/60407V6YG

#Breaking: We’re excited to share positive results from the Phase III trial evaluating our investigational BTK inhibitor in people living with primary progressive multiple sclerosis (PPMS) and relapsing multiple sclerosis (RMS). We believe this BTKi has the potential to become the first high-efficacy, oral treatment that can help people with both RMS and PPMS. We continually push the boundaries of innovation and research in multiple sclerosis, reaffirming our enduring commitment to the MS community to deliver best-in-disease medicines. Learn more about the data and our ongoing efforts to address both forms of progression: http://spr.ly/60437T35F

We're excited to announce that applications are open for our 2026 Graduate Student Symposium (May 5-6). Designed for 4th-year Ph.D. students in Organic Chemistry, Chemical Biology, or Computational Chemistry, this symposium offers unparalleled networking with biotech professionals and an exclusive campus tour. Apply before December 31st to secure your spot. http://spr.ly/60477PhnN

From experimenting with chemical reactions growing up in Germany to developing small molecule medicines, Joachim Rudolph’s career is a testament to the power of curiosity and collaboration. Discover how his leadership inspires bold exploration. http://spr.ly/60407M4IY

Antimicrobial resistance is one of the greatest public health challenges of our time. To combat this, our scientists, in collaboration with Mila - Institut québécois d'intelligence artificielle and NVIDIA Healthcare, developed GNEprop, an AI-powered molecular screening model designed to help our scientists identify new classes of antibiotics with the potential to target gram-negative bacteria. This breakthrough, published in Nature Biotechnology, combines AI with experimental research to accelerate drug discovery and uncover solutions faster than ever before. Learn more about how we’re tackling antimicrobial resistance. http://spr.ly/60447zmwm

This Native American Heritage Month, we’re shining a light on how culture, art and innovation can foster community. “Of Land and Place,” a powerful new public art installation on our South San Francisco campus – created by artist Lena Wolff in collaboration with our Genentech Native Americans (gNA) employee resource group – does just that. By partnering with Lena, who created 200 custom concrete tiles for the installation, we not only honor the land our campus sits on, but integrate art and science as we reflect on the past while building a healthier and more inclusive future for all. Learn more about how we build connections among our employees: http://spr.ly/60497KT7L #NativeAmericanHeritageMonth

We announced positive results from our Phase III study for the treatment of systemic lupus erythematosus (SLE). SLE, an autoimmune disease commonly known as #lupus, can be debilitating and is widely known for causing joint pain, fatigue, and inflammation. Read more about the data: https://lnkd.in/gUY4GX6i