Query performance of a SELECT statement using WHERE and NOT IN

Can anyone help improve the performance of my query? When I run it, it locks the database for 5 to 10 minutes.

SELECT 
    u.username, 
    u.email, 
    u.created_at, 
    p.firstname, 
    p.lastname, 
    p.address, 
    p.address_2, 
    p.city, 
    p.country, 
    p.state, 
    p.zip, 
    p.phone, 
    p.phone_2, 
    u.last_ip, 
    u.last_login_at, 
    u.auto_login, 
    u.registration_page,
    s.product_name
    FROM
    users AS u
        Left Join subscriptions AS s ON u.id = s.user_id
        Left Join profiles AS p ON u.id = p.user_id
    where u.registration_page='Chris_Cleanse' and
        u.id not in (select user_id from goal_sheets) and 
        u.id not in(select user_id from sheet_user_popup_not_adam) and 
        s.expired=TRUE ORDER BY u.id DESC;

Here is the output of EXPLAIN SELECT: