I am using plupload 1.5.7. I have two buttons on page:

First one (Add new attachment) was used as browse_button in plupload configuration. When I click it, it doesn't work. Click event is executed, but file browser is not opened. But there is second button (Trigger add new attachment click), which only does this:
$('#TriggerAddNewAttachmentClickButton').click(function() {
$("#AddNewAttachmentButton").click();
})
So it only triggers click of the first button. It works fine. Clicking it opens file browser.
How is this possible? This behavior is consistent between Firefox, Chrome and Internet Explorer.
Obviously this is security related, because plupload uses tricks to hide input, but second method is not safer. I can't reproduce this issue in jsfiddle, it exists only in specific context, but maybe there is someone, who ecountered similar behaviour.