With the standard clojure repl, the class file needs to be available on the classpath used to start the repl. Here's an example
java -cp pathToClojure\clojure.jar;.\src;.\lib;.\lib\* clojure.main %1
I have the src included for clojure source, the lib folder included for class files, and lib* included for classes included in jar files.
In this example, the Speak class can be included and used with:
user=> (import Speak)
Speak
user=> (Speak/greet)
"Hello! I am a human!"
This assumes that you have set up the classpath before starting the repl. If you want to add something to the classpath after the repl is started it's more complicated. Example code to do it can be found here