Clojurescript needs to be compiled to JS if you want to execute it. That I know of there is no direct invocation method from lein cljsbuild since CLJS executes in multiple environments (node, rhino, v8, browser, etc) and each is very specific about how to run the JS, so it can't make the choice for you.
Here are a couple of quick ways of running a cljs script in node (keep in mind that the compilation will take time since it is java based and the startup time is a bit bad)
The easy way
The easiest way right now would be something like this (for executing an script in node):
lein new mies-node hello-world
cd hello-world
lein cljsbuild once
node run.js
There are more templates for node cljs, mies-node is just one of them.
The hard (but later more immediate way)
If you want the hard way, install the clojurescript compiler and then you can do something like this:
$ node -e "$(cljsc hello.cljs '{:target :nodejs :optimizations :whitespace}')"
Note: cljsc will need to be in path
Note: this may give you problems with externs and what not. play with the options you pass to the compiler