There are number of ways to do it:
Using filter() (and operator)
query = meta.Session.query(User).filter(
User.firstname.like(search_var1),
User.lastname.like(search_var2)
)
Using filter_by() (and operator)
query = meta.Session.query(User).filter_by(
firstname.like(search_var1),
lastname.like(search_var2)
)
Chaining filter() or filter_by() (and operator)
query = meta.Session.query(User).\
filter_by(firstname.like(search_var1)).\
filter_by(lastname.like(search_var2))
Using or_(), and_(), and not()
from sqlalchemy import and_, or_, not_
query = meta.Session.query(User).filter(
and_(
User.firstname.like(search_var1),
User.lastname.like(search_var2)
)
)