I've created a Github repo that has all the source code related to this question. I'm able to load build/index.html in the browser after running npm install. However, when I view the sources tab in Chrome, I don't see the source maps associated with the .tsx files.
Here's a screenshot of what I see: 
I've added sourceMap: true in my tsconfig.json as well as debug: true and devtool: "source-map" in my webpack.config.json. Any thoughts on what I'm missing here?
EDIT:
This might be a silly question, but do you have to use webpack-dev-server in order to see the sourcemaps?
npm install && typings install && npm run dev-> opened chrome -> F12 -> navigate to localhost:8080/webpack-dev-server (or localhost:8080/build - both works) and I'm seeing a log fromReactDOM.js:66andapp.tsx:14, so sourceMaps seem to be working - maybe your issue is to FIRST open the dev-tools before entering the url (or hit F5 after opening the dev-tools) - but your config seems to work. - Running Node v4.2.6 (>=4.x.x is required for Webpack i think)webpackas well aswebpack-dev-server- since it is basically the same thing, with the addition of thedev-serverautomatically serving the stuff thatwebpackpackaged. - So you can usenpm run buildornpm run devand both will generate a source-map.webpackand notwebpack-dev-server:(