Sorry, but what does this have to do with Python?! You should try to use the right tool for the job. If you need Python, R, or C#, use them; if you don't need them why use them? SQL Server and Excel work very, very, very well together. You could easily use the SQL Server Import Wizard to move the data in or out.
You could use SQL to do the job.
SELECT * INTO EXCEL_IMPORT
FROM OPENROWSET('Microsoft.ACE.OLEDB.12.0',
'Excel 12.0; Database=C:\Excel\Spreadsheet.xls; HDR=YES; IMEX=1',
'SELECT * FROM [Sheet1$]');
You can just as well use VBA to get things done.
Sub InsertInto()
'Declare some variables
Dim cnn As adodb.Connection
Dim cmd As adodb.Command
Dim strSQL As String
'Create a new Connection object
Set cnn = New adodb.Connection
'Set the connection string
cnn.ConnectionString = "Your_Server_Name;Database=Your_Database_Name;Trusted_Connection=True;"
'Create a new Command object
Set cmd = New adodb.Command
'Open the connection
cnn.Open
'Associate the command with the connection
cmd.ActiveConnection = cnn
'Tell the Command we are giving it a bit of SQL to run, not a stored procedure
cmd.CommandType = adCmdText
'Create the SQL
strSQL = "UPDATE TBL SET JOIN_DT = 2013-01-13 WHERE EMPID = 2"
'Pass the SQL to the Command object
cmd.CommandText = strSQL
'Open the Connection to the database
cnn.Open
'Execute the bit of SQL to update the database
cmd.Execute
'Close the connection again
cnn.Close
'Remove the objects
Set cmd = Nothing
Set cnn = Nothing
End Sub
https://www.excel-sql-server.com/excel-sql-server-import-export-using-vba.htm#Excel%20Data%20Export%20to%20SQL%20Server%20Test%20Code
Sorry for not answering your Python question, but I'm a huge proponent of using the right tool for the job. Python is awesome for countless things, but not this kind of thing.