How can Deserialize with Javascript Serializer? (ASP.net)

Create a class

class Data 
{
    public SocialFriends[] data { get; set; }
}

and change your code to:

Data oList2 = ser.Deserialize<Data>(response.Content);

This code works.

public class SocialFriendsData
{
    public List<SocialFriends> Data { get; set; }
}

public class SocialFriends
{
    public string id { get; set; }
    public string name { get; set; }
}

Deserialization:

 JavaScriptSerializer ser = new JavaScriptSerializer();
 string response = "{\"data\":[{\"name\":\"George\",\"id\":\"511222445\"},{\"name\":\"Mayk\",\"id\":\"517247768\"}]}";
 SocialFriendsData oList2 = ser.Deserialize<SocialFriendsData>(response);

Your JSON is wrapped in a data property. You'll have to grab the JSON string out of that data property. I don't know which JSON serializer you use, but based on what you provided, the easiest way is probably just to create an intermediate DataHolder class:

public class DataHolder
{
    public string Data { get; set; }
}

Then deserialize it like this:

var dataHolder = ser.Deserialize<DataHolder>(response.Content);
var oList2 = ser.Deserialize<List<SocialFriends>>(dataHolder.Data);

If you're using a robust JSON serializer like Json.NET, you can even skip the intermediate deserialization and change your DataHolder type to the correct type:

public class DataHolder
{
    public List<SocialFriends> SocialFriends { get; set; }
}

And then use this code to get the data:

var dataHolder = ser.Deserialize<DataHolder>(response.Content);
var oList2 = dataHolder.SocialFriends;