in addition to Laurenz's answer, if you have not so many cases where comment is null, you could just use a btree index since they can be used to look this up:
create index comments_comment_idx ON "Comments" (comment);
This gives you an ability to search on equality of comments as long as they are short enough not to be toasted. You can also search for ranges and prefixes. However if they go on for a few kb, you may start to run into problems, so recommend using this approach only if comments are expected to be reasonably short.
As a further note there are other ways of optimising such a query as well. As a further note, if you are doing a lot of ordering by id you may want to do a multi-column index that would allow an index-only scan:
create index comments_comment_id_idx ON "Comments" (id, comment);
That would be useful if you want the last five ids where comment is not null for example.
create index on "Comments" (id) where comment is not null?