In addition, and based on some answers above. Cleaned some code. Very easy approach.
Just change @tablename and @columnname:
SET @dbname = DATABASE();
SET @tablename = "tableName";
SET @columnname = "IX_Table_XYZ";
SET @preparedStatement = (SELECT IF(
(
SELECT COUNT(*) FROM INFORMATION_SCHEMA.STATISTICS
WHERE
(table_name = @tablename)
AND (table_schema = @dbname)
AND (index_name = @columnname)
) > 0,
"SELECT 1",
CONCAT("ALTER TABLE ", @tablename, " ADD INDEX ", @columnname, " (", @columnname, ") USING BTREE;")
));
PREPARE alterIfNotExists FROM @preparedStatement;
EXECUTE alterIfNotExists;
DEALLOCATE PREPARE alterIfNotExists;